Accurate, low-power, and compact temperature sensors are demanded in a wide range of biomedical, environmental, and industrial sensing applications. This article presents an accurate and precise CMOS temperature sensor based on a sub-threshold ring oscillator (RO) in 180 nm. The sensing core employs a five-stage super cut-off contention-free (SCCF) delay cell to closely mimic the temperature dependency of a single MOSFET, minimizing the errors in current-to-frequency conversion and achieving a −0.065 °C/ +0.061 °C inaccuracy after 2-point calibration and ±0.26 °C after 1-point calibration from −20 °C to 100 °C. Meanwhile, a self-biased 3-transistor (3T) header significantly reduces the supply line sensitivity to 0.02 °C/V and achieves less than 0.2 °C temperature drift after more than 180 h of accelerated aging. The aging-induced drift is reduced to 0.11 °C with a calibration after 30 h of pre-aging. Additionally, this work introduces an adaptive uniform resolution counter to maintain a consistent and programmable resolution across the wide temperature range, despite the sub-threshold RO’s exponential dependency on temperature. The prototyping sensor in 180-nm CMOS consumes only 33 nW at 20 °C and occupies 0.028 mm² area. Beyond standard circuit testing, the 1-pt calibrated sensor was validated in a multi-day in vivo animal body temperature tracking experiment and outperformed off-the-shelf solutions.